Synthesis and biological evaluation of a new chalconate Co (II/III) complex with cytotoxic activity

Manos C. Vlasiou; Kyriacos Ioannou; Constantina Eleftheriou; Kyriaki S. Pafiti; Lefteris C. Zacharia; Mohamed El-Shazly

doi:10.1016/j.molstruc.2021.131567

Synthesis and biological evaluation of a new chalconate Co (II/III) complex with cytotoxic activity

Manos C. Vlasiou, Kyriacos Ioannou, Constantina Eleftheriou, Kyriaki S. Pafiti, Lefteris C. Zacharia, Mohamed El-Shazly

School of Life and Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

A newly synthesized chalcone derivative was used as a ligand to form a stable cobalt (II/III) complex. The cytotoxic activity of the complex was evaluated against breast cancer cells MDA-MB-231. The prooxidant and DNA binding activity of the complex was also evaluated. The complex showed prooxidant activity and potent binding tendency with the base pairs DNA. Molecular docking theoretical studies supported our findings by showing that the complex interacted with several breast cancer-related protein structures.

Original language	English
Article number	131567
Journal	Journal of Molecular Structure
Volume	1249
DOIs	https://doi.org/10.1016/j.molstruc.2021.131567
Publication status	Published - 5 Feb 2022

Keywords

Anticancer
Biological evaluation
Cobalt
Metal complexes
Synthesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.molstruc.2021.131567

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title = "Synthesis and biological evaluation of a new chalconate Co (II/III) complex with cytotoxic activity",

abstract = "A newly synthesized chalcone derivative was used as a ligand to form a stable cobalt (II/III) complex. The cytotoxic activity of the complex was evaluated against breast cancer cells MDA-MB-231. The prooxidant and DNA binding activity of the complex was also evaluated. The complex showed prooxidant activity and potent binding tendency with the base pairs DNA. Molecular docking theoretical studies supported our findings by showing that the complex interacted with several breast cancer-related protein structures.",

keywords = "Anticancer, Biological evaluation, Cobalt, Metal complexes, Synthesis",

author = "Vlasiou, {Manos C.} and Kyriacos Ioannou and Constantina Eleftheriou and Pafiti, {Kyriaki S.} and Zacharia, {Lefteris C.} and Mohamed El-Shazly",

note = "Funding Information: The authors are thankful to Dr. Demetris Apostolides, Department of Chemistry, the University of Cyprus for assisting in the NMR experiments. Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

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doi = "10.1016/j.molstruc.2021.131567",

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T1 - Synthesis and biological evaluation of a new chalconate Co (II/III) complex with cytotoxic activity

AU - Vlasiou, Manos C.

AU - Ioannou, Kyriacos

AU - Eleftheriou, Constantina

AU - Pafiti, Kyriaki S.

AU - Zacharia, Lefteris C.

AU - El-Shazly, Mohamed

N1 - Funding Information: The authors are thankful to Dr. Demetris Apostolides, Department of Chemistry, the University of Cyprus for assisting in the NMR experiments. Publisher Copyright: © 2021 Elsevier B.V.

PY - 2022/2/5

Y1 - 2022/2/5

N2 - A newly synthesized chalcone derivative was used as a ligand to form a stable cobalt (II/III) complex. The cytotoxic activity of the complex was evaluated against breast cancer cells MDA-MB-231. The prooxidant and DNA binding activity of the complex was also evaluated. The complex showed prooxidant activity and potent binding tendency with the base pairs DNA. Molecular docking theoretical studies supported our findings by showing that the complex interacted with several breast cancer-related protein structures.

AB - A newly synthesized chalcone derivative was used as a ligand to form a stable cobalt (II/III) complex. The cytotoxic activity of the complex was evaluated against breast cancer cells MDA-MB-231. The prooxidant and DNA binding activity of the complex was also evaluated. The complex showed prooxidant activity and potent binding tendency with the base pairs DNA. Molecular docking theoretical studies supported our findings by showing that the complex interacted with several breast cancer-related protein structures.

KW - Anticancer

KW - Biological evaluation

KW - Cobalt

KW - Metal complexes

KW - Synthesis

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VL - 1249

JO - Journal of Molecular Structure

JF - Journal of Molecular Structure

M1 - 131567

ER -

Synthesis and biological evaluation of a new chalconate Co (II/III) complex with cytotoxic activity

Abstract

Keywords

UN SDGs

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