A newly synthesized chalcone derivative was used as a ligand to form a stable cobalt (II/III) complex. The cytotoxic activity of the complex was evaluated against breast cancer cells MDA-MB-231. The prooxidant and DNA binding activity of the complex was also evaluated. The complex showed prooxidant activity and potent binding tendency with the base pairs DNA. Molecular docking theoretical studies supported our findings by showing that the complex interacted with several breast cancer-related protein structures.
- Biological evaluation
- Metal complexes