Synthesis of a protected δ-glyco-amino acid building block for incorporation into peptide chains

George Paloumbis, Christos C. Petrou, Berthold Nock, Theodosia Maina, George Pairas, Petros G. Tsoungas, Paul Cordopatis

Research output: Contribution to journalArticlepeer-review

Abstract

The synthesis of a suitably protected sugar amino acid (δ-glyco-amino acid) as a building block to be incorporated into the peptide chain (N-terminus) of bioactive peptide analogues is described. Its efficient coupling reactions with pilot amino acids as well as dipeptides have been accomplished by standard peptide chemistry.

Original languageEnglish
Pages (from-to)845-852
Number of pages8
JournalSynthesis
Issue number6
DOIs
Publication statusPublished - 16 Mar 2007

Keywords

  • δ-glyco-amino acid
  • Carbohydrates
  • Glycopeptides
  • Glycosylation
  • Radiolabelling

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