TY - JOUR
T1 - Synthesis of triazole-functionalized 2-DOS analogues and their evaluation as A-site binders
AU - Anastasopoulou, Panoula
AU - Kythreoti, Georgia
AU - Cosmidis, Tilemachos
AU - Pyrkotis, Constantina
AU - Nahmias, Victoria R.
AU - Vourloumis, Dionisios
PY - 2014/2/15
Y1 - 2014/2/15
N2 - Aminoglycoside-antibiotics represent important tools for studying the biological functions of RNA. An orthogonal protection strategy applied on 2-deoxystreptamine (2-DOS) revealed a series of key intermediates that enable its regioselective functionalization. Our approach allowed the construction of selected representatives of triazole-containing analogues with diverse molecular frameworks for biological evaluation regarding their binding and antibacterial potencies.
AB - Aminoglycoside-antibiotics represent important tools for studying the biological functions of RNA. An orthogonal protection strategy applied on 2-deoxystreptamine (2-DOS) revealed a series of key intermediates that enable its regioselective functionalization. Our approach allowed the construction of selected representatives of triazole-containing analogues with diverse molecular frameworks for biological evaluation regarding their binding and antibacterial potencies.
KW - 2-Deoxystreptamine
KW - Aminoglycosides
KW - Orthogonal protection strategy
KW - Ribosomal A-site
KW - RNA recognition
UR - http://www.scopus.com/inward/record.url?scp=84893790198&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2013.12.125
DO - 10.1016/j.bmcl.2013.12.125
M3 - Article
C2 - 24440302
AN - SCOPUS:84893790198
SN - 0960-894X
VL - 24
SP - 1122
EP - 1126
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 4
ER -