Abstract
The C18-C29 segment of amphidinolide F is synthesised in 12 steps from 1,4-butanediol. Key steps include a mono-Sharpless dihydroxylation of a dienoate, iodocyclisation to construct the trans-THF ring and an E-selective Wittig reaction to introduce the C25-C26 olefin.
Original language | English |
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Pages (from-to) | 3325-3328 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 50 |
Issue number | 26 |
DOIs | |
Publication status | Published - 1 Jul 2009 |
Keywords
- Cyclisations
- Dihydroxylations
- Iodine
- Natural products
- Wittig reactions