Synthetic studies on amphidinolides C and F: synthesis of the C18-C29 segment of amphidinolide F

Alan Armstrong, Constantina Pyrkotis

Research output: Contribution to journalArticlepeer-review

Abstract

The C18-C29 segment of amphidinolide F is synthesised in 12 steps from 1,4-butanediol. Key steps include a mono-Sharpless dihydroxylation of a dienoate, iodocyclisation to construct the trans-THF ring and an E-selective Wittig reaction to introduce the C25-C26 olefin.

Original languageEnglish
Pages (from-to)3325-3328
Number of pages4
JournalTetrahedron Letters
Volume50
Issue number26
DOIs
Publication statusPublished - 1 Jul 2009

Keywords

  • Cyclisations
  • Dihydroxylations
  • Iodine
  • Natural products
  • Wittig reactions

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