T cell lymphoblastic lymphoma in parotidectomy for Warthin's tumor: Case report and review of the literature

Konstantinos Giaslakiotis, Athina Androulaki, George Panagoulias, Maria Christina Kyrtsonis, Andreas C. Lazaris, Dimitrios N. Kanakis, Efstratios S. Patsouris

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Lymphomas associated with Warthin's tumor (WT) are extremely uncommon and the majorities are of B cell type. We report the simultaneous occurrence of T-cell lymphoblastic lymphoma (T-LBL) and WT in an 81-year-old patient, who presented with fever, night sweats and enlargement of the right parotid gland. The parotidectomy specimen showed a WT with extensive replacement of the lymphoid stroma by T-LBL, but preservation of the oncocytic epithelium. Staging investigations revealed mediastinal and abdominal lymphadenopathy, bilateral pleural effusions and bone marrow infiltration, in keeping with stage IVB disease. The patient received combination chemotherapy treatment but responded poorly, and died three months after diagnosis. To our knowledge, this is the first case report of T-LBL involving WT. The present study indicates that the lymphoid stroma in WT belongs to the systemic lymphoid tissue and can be involved in disseminated lymphoma. It highlights the importance of careful examination of WT's lymphoid stroma for the possible presence of any coexistent malignancy.

Original languageEnglish
Pages (from-to)359-364
Number of pages6
JournalInternational Journal of Hematology
Volume89
Issue number3
DOIs
Publication statusPublished - Apr 2009

Keywords

  • Collision tumor
  • Parotid gland
  • T cell lymphoblastic lymphoma
  • Warthin's tumor

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