TY - JOUR
T1 - T cell lymphoblastic lymphoma in parotidectomy for Warthin's tumor
T2 - Case report and review of the literature
AU - Giaslakiotis, Konstantinos
AU - Androulaki, Athina
AU - Panagoulias, George
AU - Kyrtsonis, Maria Christina
AU - Lazaris, Andreas C.
AU - Kanakis, Dimitrios N.
AU - Patsouris, Efstratios S.
PY - 2009/4
Y1 - 2009/4
N2 - Lymphomas associated with Warthin's tumor (WT) are extremely uncommon and the majorities are of B cell type. We report the simultaneous occurrence of T-cell lymphoblastic lymphoma (T-LBL) and WT in an 81-year-old patient, who presented with fever, night sweats and enlargement of the right parotid gland. The parotidectomy specimen showed a WT with extensive replacement of the lymphoid stroma by T-LBL, but preservation of the oncocytic epithelium. Staging investigations revealed mediastinal and abdominal lymphadenopathy, bilateral pleural effusions and bone marrow infiltration, in keeping with stage IVB disease. The patient received combination chemotherapy treatment but responded poorly, and died three months after diagnosis. To our knowledge, this is the first case report of T-LBL involving WT. The present study indicates that the lymphoid stroma in WT belongs to the systemic lymphoid tissue and can be involved in disseminated lymphoma. It highlights the importance of careful examination of WT's lymphoid stroma for the possible presence of any coexistent malignancy.
AB - Lymphomas associated with Warthin's tumor (WT) are extremely uncommon and the majorities are of B cell type. We report the simultaneous occurrence of T-cell lymphoblastic lymphoma (T-LBL) and WT in an 81-year-old patient, who presented with fever, night sweats and enlargement of the right parotid gland. The parotidectomy specimen showed a WT with extensive replacement of the lymphoid stroma by T-LBL, but preservation of the oncocytic epithelium. Staging investigations revealed mediastinal and abdominal lymphadenopathy, bilateral pleural effusions and bone marrow infiltration, in keeping with stage IVB disease. The patient received combination chemotherapy treatment but responded poorly, and died three months after diagnosis. To our knowledge, this is the first case report of T-LBL involving WT. The present study indicates that the lymphoid stroma in WT belongs to the systemic lymphoid tissue and can be involved in disseminated lymphoma. It highlights the importance of careful examination of WT's lymphoid stroma for the possible presence of any coexistent malignancy.
KW - Collision tumor
KW - Parotid gland
KW - T cell lymphoblastic lymphoma
KW - Warthin's tumor
UR - http://www.scopus.com/inward/record.url?scp=67649208586&partnerID=8YFLogxK
U2 - 10.1007/s12185-009-0271-z
DO - 10.1007/s12185-009-0271-z
M3 - Article
C2 - 19294485
AN - SCOPUS:67649208586
SN - 0925-5710
VL - 89
SP - 359
EP - 364
JO - International Journal of Hematology
JF - International Journal of Hematology
IS - 3
ER -