Targeting Inflammation to Improve Tumor Drug Delivery

Vasiliki Gkretsi, Lefteris C. Zacharia, Triantafyllos Stylianopoulos

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Inefficient delivery of drugs is a main cause of chemotherapy failure in hypoperfused tumors. To enhance perfusion and drug delivery in these tumors, two strategies have been developed: vascular normalization, aiming at normalizing tumor vasculature and blood vessel leakiness, and stress alleviation, aiming at decompressing tumor vessels. Vascular normalization is based on anti-angiogenic drugs, whereas stress alleviation is based on stroma-depleting agents. We present here an alternative approach to normalize tumor vasculature, taking into account that malignant tumors tend to develop at sites of chronic inflammation. Similarly to tumor vessel leakiness, inflammation is also characterized by vascular hyperpermeability. Therefore, testing the ability of anti-inflammatory agents, such as non-steroidal anti-inflammatory drugs (NSAIDs) or inflammation resolution mediators, as an alternative means to increase tumor drug delivery might prove promising.

Original languageEnglish
Pages (from-to)621-630
Number of pages10
JournalTrends in Cancer
Volume3
Issue number9
DOIs
Publication statusPublished - 1 Sep 2017

Keywords

  • anti-inflammatory agents
  • inflammation resolution
  • stress alleviation
  • tumor perfusion
  • vascular normalization

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