Temporal dynamics of BOLD fMRI at the microscopic level

C. Hadjistassou; K. Moyle; Y. Ventikos

Temporal dynamics of BOLD fMRI at the microscopic level

C. Hadjistassou, K. Moyle, Y. Ventikos

Department of Engineering

University of Oxford

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

With the prospect of elucidating the BOLD fMRI phenomenon we consider the interactions between Cerebral Blood Flow (CBF), oxygen utilization (CMRO ₂), haemoglobin reaction kinetics, and oxygen transport. This paper presents four cases that mimic the physiological response of the brain subject to cerebral activation/inactivation transitions and changes in CBF. Model results show that the system is more sensitive to changes in CBF rather than alterations in CMRO₂. Thus given the small magnitude of BOLD fMRI signal (0.5% to 5%)[1] the relative feedback reactions between CMRO₂ and CBF appear to play a pivotal role in elucidating BOLD fMRI.

Original language	English
Title of host publication	2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings
Pages	650-653
Number of pages	4
Volume	1
Publication status	Published - 2007
Event	2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007 - Santa Clara, CA, United States Duration: 20 May 2007 → 24 May 2007

Other

Other	2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007
Country/Territory	United States
City	Santa Clara, CA
Period	20/05/07 → 24/05/07

Keywords

BOLD fMRI
Capillary
Oxygen saturation/transport

Cite this

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title = "Temporal dynamics of BOLD fMRI at the microscopic level",

abstract = "With the prospect of elucidating the BOLD fMRI phenomenon we consider the interactions between Cerebral Blood Flow (CBF), oxygen utilization (CMRO 2), haemoglobin reaction kinetics, and oxygen transport. This paper presents four cases that mimic the physiological response of the brain subject to cerebral activation/inactivation transitions and changes in CBF. Model results show that the system is more sensitive to changes in CBF rather than alterations in CMRO2. Thus given the small magnitude of BOLD fMRI signal (0.5% to 5%)[1] the relative feedback reactions between CMRO2 and CBF appear to play a pivotal role in elucidating BOLD fMRI.",

keywords = "BOLD fMRI, Capillary, Oxygen saturation/transport",

author = "C. Hadjistassou and K. Moyle and Y. Ventikos",

year = "2007",

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volume = "1",

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booktitle = "2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings",

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TY - GEN

T1 - Temporal dynamics of BOLD fMRI at the microscopic level

AU - Hadjistassou, C.

AU - Moyle, K.

AU - Ventikos, Y.

PY - 2007

Y1 - 2007

N2 - With the prospect of elucidating the BOLD fMRI phenomenon we consider the interactions between Cerebral Blood Flow (CBF), oxygen utilization (CMRO 2), haemoglobin reaction kinetics, and oxygen transport. This paper presents four cases that mimic the physiological response of the brain subject to cerebral activation/inactivation transitions and changes in CBF. Model results show that the system is more sensitive to changes in CBF rather than alterations in CMRO2. Thus given the small magnitude of BOLD fMRI signal (0.5% to 5%)[1] the relative feedback reactions between CMRO2 and CBF appear to play a pivotal role in elucidating BOLD fMRI.

AB - With the prospect of elucidating the BOLD fMRI phenomenon we consider the interactions between Cerebral Blood Flow (CBF), oxygen utilization (CMRO 2), haemoglobin reaction kinetics, and oxygen transport. This paper presents four cases that mimic the physiological response of the brain subject to cerebral activation/inactivation transitions and changes in CBF. Model results show that the system is more sensitive to changes in CBF rather than alterations in CMRO2. Thus given the small magnitude of BOLD fMRI signal (0.5% to 5%)[1] the relative feedback reactions between CMRO2 and CBF appear to play a pivotal role in elucidating BOLD fMRI.

KW - BOLD fMRI

KW - Capillary

KW - Oxygen saturation/transport

UR - http://www.scopus.com/inward/record.url?scp=34548023061&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:34548023061

SN - 1420063421

SN - 9781420063424

SN - 1420061828

SN - 9781420061826

VL - 1

SP - 650

EP - 653

BT - 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings

T2 - 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007

Y2 - 20 May 2007 through 24 May 2007

ER -

Temporal dynamics of BOLD fMRI at the microscopic level

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