The acute and chronic effects of (+) and (-) oxaprotiline upon melatonin secretion in normal subjects

E. Palazidou, D. Skene, J. Arendt, B. Everitt, S. A. Checkley

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Ten healthy male subjects were treated for three weeks with (+)oxaprotiline, a selective inhibitor of noradrenaline (NA) uptake and with (-)oxaprotiline which does not inhibit NA uptake. Plasma melatonin concentrations were measured throughout the night at 0, 1, 7 and 21 days and were higher during treatment with (+)oxaprotiline than with (-)oxaprotiline for the entire three weeks of treatment. Since NA stimulates the production and secretion of melatonin, these results are consistent with a sustained increase in noradrenergic activity within the pineal, during 21 days of treatment with an effective NA uptake inhibitor.

Original languageEnglish
Pages (from-to)61-67
Number of pages7
JournalPsychological Medicine
Volume22
Issue number1
DOIs
Publication statusPublished - 1992

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