TY - JOUR
T1 - The association of dietary patterns with high-risk human papillomavirus infection and cervical cancer
T2 - A cross-sectional study in Italy
AU - Barchitta, Martina
AU - Maugeri, Andrea
AU - Quattrocchi, Annalisa
AU - Agrifoglio, Ottavia
AU - Scalisi, Aurora
AU - Agodi, Antonella
N1 - Funding Information:
Acknowledgments: This paper has been prepared as part of the project “Non-communicable diseases risk: an integrated approach of nutritional and molecular epidemiology”, led by A.A., funded by Department of Medical and Surgical Sciences and Advanced Technologies “GF Ingrassia”, University of Catania, Italy. We are grateful to Bench Srl, University of Catania, Italy for assistance in data analysis.
Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2018/4/11
Y1 - 2018/4/11
N2 - Specific foods and nutrients help prevent the progression of persistent high-risk human papillomavirus (hrHPV) infection to cervical cancer (CC). The aim of this study was to investigate dietary patterns which may be associated with hrHPV status and the risk of high-grade cervical intraepithelial neoplasia (CIN2+). Overall, 539 eligible women, including 127 with CIN2+, were enrolled in a cross-sectional study, and tested for hrHPV infection. Food intake was estimated using a food frequency questionnaire. Logistic regression models were applied. Using the Mediterranean Diet Score, we demonstrated that, among 252 women with a normal cervical epithelium, medium adherence to the Mediterranean diet decreased the odds of hrHPV infection when compared to low adherence (adjOR = 0.40, 95%CI = 0.22–0.73). Using the principal component analysis, we also identified two dietary patterns which explained 14.31% of the variance in food groups intake. Women in the third and fourth quartiles of the “Western pattern” had higher odds of hrHPV infection when compared with first quartile (adjOR = 1.77, 95% CI = 1.04–3.54 and adjOR = 1.97, 95%CI = 1.14–4.18, respectively). Adjusting for hrHPV status and age, women in the third quartile of the “prudent pattern” had lower odds of CIN2+ when compared with those in the first quartile (OR = 0.50, 95%CI = 0.26–0.98). Our study is the first to demonstrate the association of dietary patterns with hrHPV infection and CC and discourages unhealthy habits in favour of a Mediterranean-like diet.
AB - Specific foods and nutrients help prevent the progression of persistent high-risk human papillomavirus (hrHPV) infection to cervical cancer (CC). The aim of this study was to investigate dietary patterns which may be associated with hrHPV status and the risk of high-grade cervical intraepithelial neoplasia (CIN2+). Overall, 539 eligible women, including 127 with CIN2+, were enrolled in a cross-sectional study, and tested for hrHPV infection. Food intake was estimated using a food frequency questionnaire. Logistic regression models were applied. Using the Mediterranean Diet Score, we demonstrated that, among 252 women with a normal cervical epithelium, medium adherence to the Mediterranean diet decreased the odds of hrHPV infection when compared to low adherence (adjOR = 0.40, 95%CI = 0.22–0.73). Using the principal component analysis, we also identified two dietary patterns which explained 14.31% of the variance in food groups intake. Women in the third and fourth quartiles of the “Western pattern” had higher odds of hrHPV infection when compared with first quartile (adjOR = 1.77, 95% CI = 1.04–3.54 and adjOR = 1.97, 95%CI = 1.14–4.18, respectively). Adjusting for hrHPV status and age, women in the third quartile of the “prudent pattern” had lower odds of CIN2+ when compared with those in the first quartile (OR = 0.50, 95%CI = 0.26–0.98). Our study is the first to demonstrate the association of dietary patterns with hrHPV infection and CC and discourages unhealthy habits in favour of a Mediterranean-like diet.
KW - Cervical intraepithelial neoplasia
KW - Mediterranean diet score
KW - Principal component analysis
KW - Prudent diet
KW - Western diet
UR - http://www.scopus.com/inward/record.url?scp=85045415725&partnerID=8YFLogxK
U2 - 10.3390/nu10040469
DO - 10.3390/nu10040469
M3 - Article
C2 - 29641467
AN - SCOPUS:85045415725
SN - 2072-6643
VL - 10
JO - Nutrients
JF - Nutrients
IS - 4
M1 - 469
ER -