TY - JOUR
T1 - The burden of Alzheimer's disease and other types of dementia in the Middle East and North Africa region, 1990-2019
AU - Safiri, Saeid
AU - Noori, Maryam
AU - Nejadghaderi, Seyed Aria
AU - Mousavi, Seyed Ehsan
AU - Sullman, Mark J.M.
AU - Araj-Khodaei, Mostafa
AU - Collins, Gary S.
AU - Kolahi, Ali Asghar
AU - Gharagozli, Kurosh
N1 - Publisher Copyright:
© The Author(s) 2023. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: [email protected].
PY - 2023/3/1
Y1 - 2023/3/1
N2 - BACKGROUND: Alzheimer's disease (AD) is the most common cause of dementia and this progressive neurological disorder is associated with substantial mortality and morbidity. We aimed to report the burden of AD and other types of dementia in the Middle East and North Africa (MENA) region, by age, sex and sociodemographic index (SDI), for the period 1990-2019. METHODS: publicly accessible data on the prevalence, death and disability-adjusted life years (DALYs) because of AD, and other types of dementia, were retrieved from the global burden of disease 2019 project for all MENA countries from 1990 to 2019. RESULTS: in 2019, the age-standardised point prevalence of dementia was 777.6 per 100,000 populations in MENA, which was 3.0% higher than in 1990. The age-standardised death and DALY rates of dementia were 25.5 and 387.0 per 100,000, respectively. In 2019, the highest DALY rate was observed in Afghanistan and the lowest rate was in Egypt. That same year, the age-standardised point prevalence, death and DALY rates increased with advancing age and were higher for females of all age groups. From 1990 to 2019, the DALY rate of dementia decreased with increasing SDI up to 0.4, then slightly increased up to an SDI of 0.75, followed by a decrease for the remaining SDI levels. CONCLUSIONS: the point prevalence of AD and other types of dementia has increased over the past three decades, and in 2019, the corresponding regional burden was higher than the global average.
AB - BACKGROUND: Alzheimer's disease (AD) is the most common cause of dementia and this progressive neurological disorder is associated with substantial mortality and morbidity. We aimed to report the burden of AD and other types of dementia in the Middle East and North Africa (MENA) region, by age, sex and sociodemographic index (SDI), for the period 1990-2019. METHODS: publicly accessible data on the prevalence, death and disability-adjusted life years (DALYs) because of AD, and other types of dementia, were retrieved from the global burden of disease 2019 project for all MENA countries from 1990 to 2019. RESULTS: in 2019, the age-standardised point prevalence of dementia was 777.6 per 100,000 populations in MENA, which was 3.0% higher than in 1990. The age-standardised death and DALY rates of dementia were 25.5 and 387.0 per 100,000, respectively. In 2019, the highest DALY rate was observed in Afghanistan and the lowest rate was in Egypt. That same year, the age-standardised point prevalence, death and DALY rates increased with advancing age and were higher for females of all age groups. From 1990 to 2019, the DALY rate of dementia decreased with increasing SDI up to 0.4, then slightly increased up to an SDI of 0.75, followed by a decrease for the remaining SDI levels. CONCLUSIONS: the point prevalence of AD and other types of dementia has increased over the past three decades, and in 2019, the corresponding regional burden was higher than the global average.
KW - Alzheimer’s disease and other types of dementia
KW - disability-adjusted life-years
KW - epidemiology
KW - Middle East and North Africa
KW - mortality
KW - older people
KW - prevalence
UR - http://www.scopus.com/inward/record.url?scp=85151573665&partnerID=8YFLogxK
U2 - 10.1093/ageing/afad042
DO - 10.1093/ageing/afad042
M3 - Article
C2 - 36995136
AN - SCOPUS:85151573665
SN - 1468-2834
VL - 52
JO - Age and ageing
JF - Age and ageing
IS - 3
ER -