TY - JOUR
T1 - The double face of cold in cancer
AU - Voskarides, Konstantinos
N1 - Publisher Copyright:
© 2022
PY - 2023/2
Y1 - 2023/2
N2 - In a recent paper published in Nature, multiple evidence is provided that cold exposure causes tumor growth restriction in mice, by activating brown adipose tissue metabolism and by subsequent cancer cells’ glucose starvation. The paper shows a tumor growth inhibition by 80% for multiple cancer types in mice exposed to 4 °C in comparison with mice exposed to 30 °C. These results are very promising since cost effective protocols could be designed for future clinical trials, for several cancer forms. In this commentary, an extensive analysis is performed on the potential of these results. Some previous published studies are discussed as well, showing differences in tumor growth for mice housed in different external temperatures.
AB - In a recent paper published in Nature, multiple evidence is provided that cold exposure causes tumor growth restriction in mice, by activating brown adipose tissue metabolism and by subsequent cancer cells’ glucose starvation. The paper shows a tumor growth inhibition by 80% for multiple cancer types in mice exposed to 4 °C in comparison with mice exposed to 30 °C. These results are very promising since cost effective protocols could be designed for future clinical trials, for several cancer forms. In this commentary, an extensive analysis is performed on the potential of these results. Some previous published studies are discussed as well, showing differences in tumor growth for mice housed in different external temperatures.
UR - http://www.scopus.com/inward/record.url?scp=85144793353&partnerID=8YFLogxK
U2 - 10.1016/j.tranon.2022.101606
DO - 10.1016/j.tranon.2022.101606
M3 - Article
AN - SCOPUS:85144793353
SN - 1936-5233
VL - 28
JO - Translational Oncology
JF - Translational Oncology
M1 - 101606
ER -