The GB hepatitis viruses

P. Karayiannis, M. J. McGarvey

Research output: Contribution to journalReview articlepeer-review


Summary. The genomes of three new flavi‐like viruses, GBV‐A, GBV‐B and GBV‐C have been identified. Nucleic acid molecules corresponding to the genomes of GBV‐A and GBV‐B were isolated from tamarins with hepatitis which had been infected with the GB agent. RNA sequences corresponding to GBV‐C have been shown to be present in sera from humans with non‐A‐E hepatitis. Sequence comparisons show that these three viruses are more closely related to each other and to hepatitis C virus (HCV) than to any other known viruses. Together with HCV they appear to form a discrete cluster of related viruses within the larger genus of flaviviridae. The pathological significance of these viruses and their association with hepatitis is currently emerging.

Original languageEnglish
Pages (from-to)221-226
Number of pages6
JournalJournal of Viral Hepatitis
Issue number5
Publication statusPublished - 1995


  • flavivirus
  • GB virus
  • HCV
  • non‐A non‐B hepatitis


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