The in vitro transport of model thiodipeptide prodrugs designed to target the intestinal oligopeptide transporter, PepT1

David Foley, Myrtani Pieri, Rachel Pettecrew, Richard Price, Stephen Miles, Ho Kam Lam, Patrick Bailey, David Meredith

Research output: Contribution to journalArticlepeer-review

Abstract

A thiodipeptide carrier system is shown to be effective at enabling a range of covalently bound molecules, including benzyl, benzoyl and ibuprofen conjugates, to be transported via the intestinal peptide transporter PepT1, demonstrating its potential as a rational drug delivery target.

Original languageEnglish
Pages (from-to)3652-3656
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume7
Issue number18
DOIs
Publication statusPublished - 2009

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