The in vitro transport of model thiodipeptide prodrugs designed to target the intestinal oligopeptide transporter, PepT1

David Foley; Myrtani Pieri; Rachel Pettecrew; Richard Price; Stephen Miles; Ho Kam Lam; Patrick Bailey; David Meredith

doi:10.1039/b909221h

The in vitro transport of model thiodipeptide prodrugs designed to target the intestinal oligopeptide transporter, PepT1

David Foley
, Myrtani Pieri
, Rachel Pettecrew
, Richard Price
, Stephen Miles
, Ho Kam Lam
, Patrick Bailey
, David Meredith

Research output: Contribution to journal › Article › peer-review

Abstract

A thiodipeptide carrier system is shown to be effective at enabling a range of covalently bound molecules, including benzyl, benzoyl and ibuprofen conjugates, to be transported via the intestinal peptide transporter PepT1, demonstrating its potential as a rational drug delivery target.

Original language	English
Pages (from-to)	3652-3656
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	7
Issue number	18
DOIs	https://doi.org/10.1039/b909221h
Publication status	Published - 2009

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title = "The in vitro transport of model thiodipeptide prodrugs designed to target the intestinal oligopeptide transporter, PepT1",

abstract = "A thiodipeptide carrier system is shown to be effective at enabling a range of covalently bound molecules, including benzyl, benzoyl and ibuprofen conjugates, to be transported via the intestinal peptide transporter PepT1, demonstrating its potential as a rational drug delivery target.",

author = "David Foley and Myrtani Pieri and Rachel Pettecrew and Richard Price and Stephen Miles and Lam, \{Ho Kam\} and Patrick Bailey and David Meredith",

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AU - Foley, David

AU - Pieri, Myrtani

AU - Pettecrew, Rachel

AU - Price, Richard

AU - Miles, Stephen

AU - Lam, Ho Kam

AU - Bailey, Patrick

AU - Meredith, David

PY - 2009

Y1 - 2009

N2 - A thiodipeptide carrier system is shown to be effective at enabling a range of covalently bound molecules, including benzyl, benzoyl and ibuprofen conjugates, to be transported via the intestinal peptide transporter PepT1, demonstrating its potential as a rational drug delivery target.

AB - A thiodipeptide carrier system is shown to be effective at enabling a range of covalently bound molecules, including benzyl, benzoyl and ibuprofen conjugates, to be transported via the intestinal peptide transporter PepT1, demonstrating its potential as a rational drug delivery target.

UR - https://www.scopus.com/pages/publications/69549091869

U2 - 10.1039/b909221h

DO - 10.1039/b909221h

M3 - Article

C2 - 19707666

AN - SCOPUS:69549091869

SN - 1477-0520

VL - 7

SP - 3652

EP - 3656

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 18

ER -

The in vitro transport of model thiodipeptide prodrugs designed to target the intestinal oligopeptide transporter, PepT1

Abstract

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