TY - JOUR
T1 - The nos3-786 t/c polymorphism is associated with power performance in adolescent male basketball players
AU - ARGYROU, Marios
AU - PIERI, Myrtani
AU - KOUSSIS, Lefkios PAI
AU - KYRIAKOU, Skevi
AU - SALIS, Philippos C.PAT
AU - FELEKKIS, Kyriacos
AU - HADJICHARALAMBOUS, Marios
N1 - Publisher Copyright:
© 2021 Edizioni Minerva Medica. All rights reserved.
PY - 2021/7
Y1 - 2021/7
N2 - BACKGROUND: The -786 T/C polymorphism of the NOS3 gene (rs2070744) has been previously linked to athletic performance with the T allele found to be present in higher frequency in power-oriented athletes. Still, what remains elusive is the putative effect of this polymorphism on specific measures of physical fitness and technical condition. In this study we examined whether the NOS3-786 T/C genotype is correlated with specific physical or technical skills in a cohort of adolescent basketball players. METHODS: 85 young basketball players (59 boys and 26 girls) were evaluated in various physical fitness parameters (agility, flexibility, speed, jumping ability, and aerobic capacity) as well as technical skills (dribbling, shooting). All players were also genotyped for the NOS3-786 T/C polymorphism. RESULTS: The frequency of the TT genotype was positively correlated with better performance in flying sprints times (10-20 secs; P=0.05, 5-10 secs; P=0.02, and 5-20 secs; P=0.01) as well as with counter movement jump (CMJ) (P=0.03) in boys. The heterozygous CT genotype was correlated with better performance in the agility test for girls. In both sexes, no differences were found between the other physical fitness parameters evaluated (P>0.05). CONCLUSIONS: The NOS3-786 TT genotype appears to be correlated with better performance in speeds and jumps in boys. These data agree with current literature associating the NOS3-786 TT genotype with power elite athletes. The molecular mechanism by which the TT genotype may confer an advantage in power exercises is still under investigation.
AB - BACKGROUND: The -786 T/C polymorphism of the NOS3 gene (rs2070744) has been previously linked to athletic performance with the T allele found to be present in higher frequency in power-oriented athletes. Still, what remains elusive is the putative effect of this polymorphism on specific measures of physical fitness and technical condition. In this study we examined whether the NOS3-786 T/C genotype is correlated with specific physical or technical skills in a cohort of adolescent basketball players. METHODS: 85 young basketball players (59 boys and 26 girls) were evaluated in various physical fitness parameters (agility, flexibility, speed, jumping ability, and aerobic capacity) as well as technical skills (dribbling, shooting). All players were also genotyped for the NOS3-786 T/C polymorphism. RESULTS: The frequency of the TT genotype was positively correlated with better performance in flying sprints times (10-20 secs; P=0.05, 5-10 secs; P=0.02, and 5-20 secs; P=0.01) as well as with counter movement jump (CMJ) (P=0.03) in boys. The heterozygous CT genotype was correlated with better performance in the agility test for girls. In both sexes, no differences were found between the other physical fitness parameters evaluated (P>0.05). CONCLUSIONS: The NOS3-786 TT genotype appears to be correlated with better performance in speeds and jumps in boys. These data agree with current literature associating the NOS3-786 TT genotype with power elite athletes. The molecular mechanism by which the TT genotype may confer an advantage in power exercises is still under investigation.
KW - Basketball
KW - Exercise
KW - Genes
KW - Sports
UR - http://www.scopus.com/inward/record.url?scp=85117950127&partnerID=8YFLogxK
U2 - 10.23736/S0393-3660.19.04247-5
DO - 10.23736/S0393-3660.19.04247-5
M3 - Article
AN - SCOPUS:85117950127
SN - 0393-3660
VL - 180
SP - 325
EP - 332
JO - Gazzetta Medica Italiana Archivio per le Scienze Mediche
JF - Gazzetta Medica Italiana Archivio per le Scienze Mediche
IS - 7-8
ER -