The role of laparoscopy and laparoscopic ultrasound in the preoperative staging of patients with resectable colorectal liver metastases: A meta-analysis

Deepak Hariharan, Vasilis Constantinides, Hemant M. Kocher, Paris P. Tekkis

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)

Abstract

BACKGROUND: The role of staging laparoscopy (SL) with laparoscopic ultrasound (LUS) in patients with resectable colorectal liver metastases (CRLM) remains controversial. METHODS: A meta-analysis of all studies (from 1998 to the present) on the effect of SL/LUS in patients with potentially resectable CRLM with respect to alteration in surgical management was performed. RESULTS: Twelve studies satisfied the inclusion criteria. A total of 1,047 patients underwent SL/LUS. The true yield of SL/LUS for CRLM was 19% (95% confidence interval [CI], 16%-22%), with a diagnostic odds ratio of 132 (95% CI, 56-310) and an overall sensitivity of 59% (95% CI, 53%-65%). Subgroup analysis for detection of other liver and peritoneal lesions showed a sensitivity of 59% (95% CI, 49%-67%) and 75% (95% CI, 63%-85%) respectively. There was major between-study heterogeneity for all analyses, with no obvious cause revealed by meta-regression. CONCLUSIONS: The true benefit of using SL/LUS universally seems limited. It appears more useful as an adjunct in patients when peritoneal disease is suspected.

Original languageEnglish
Pages (from-to)84-92
Number of pages9
JournalAmerican Journal of Surgery
Volume204
Issue number1
DOIs
Publication statusPublished - Jul 2012

Keywords

  • Colorectal liver metastasis
  • Diagnostic accuracy
  • Laparoscopy
  • Meta-analysis
  • Peritoneal metastases

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