The Role of miRNAs as Biomarkers for Pregnancy Outcomes: A Comprehensive Review

Martina Barchitta, Andrea Maugeri, Annalisa Quattrocchi, Ottavia Agrifoglio, Antonella Agodi

Research output: Contribution to journalReview articlepeer-review

37 Citations (Scopus)

Abstract

Several studies showed that altered expression of the miRNA-ome in maternal circulation or in placental tissue may reflect not only gestational disorders, such as preeclampsia, spontaneous abortion, preterm birth, low birth weight, or macrosomia, but also prenatal exposure to environmental pollutants. Generally, the relationships between environmental exposure, changes in miRNA expression, and gestational disorders are explored separately, producing conflicting findings. However, validation of tissue-accessible biomarkers for the monitoring of adverse pregnancy outcomes needs a systematic methodological approach that takes also into account early-life environmental exposure. To achieve this goal, exposure to xenochemicals, endogenous agents, and diet should be assessed. This study has the aim to provide a comprehensive review on the role of miRNAs as potential biomarkers for adverse pregnancy outcomes and prenatal environmental exposure.

Original languageEnglish
Article number8067972
JournalInternational Journal of Genomics
Volume2017
DOIs
Publication statusPublished - 2017
Externally publishedYes

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