TY - JOUR
T1 - The Role of miRNAs as Biomarkers for Pregnancy Outcomes
T2 - A Comprehensive Review
AU - Barchitta, Martina
AU - Maugeri, Andrea
AU - Quattrocchi, Annalisa
AU - Agrifoglio, Ottavia
AU - Agodi, Antonella
N1 - Publisher Copyright:
© 2017 Martina Barchitta et al.
PY - 2017
Y1 - 2017
N2 - Several studies showed that altered expression of the miRNA-ome in maternal circulation or in placental tissue may reflect not only gestational disorders, such as preeclampsia, spontaneous abortion, preterm birth, low birth weight, or macrosomia, but also prenatal exposure to environmental pollutants. Generally, the relationships between environmental exposure, changes in miRNA expression, and gestational disorders are explored separately, producing conflicting findings. However, validation of tissue-accessible biomarkers for the monitoring of adverse pregnancy outcomes needs a systematic methodological approach that takes also into account early-life environmental exposure. To achieve this goal, exposure to xenochemicals, endogenous agents, and diet should be assessed. This study has the aim to provide a comprehensive review on the role of miRNAs as potential biomarkers for adverse pregnancy outcomes and prenatal environmental exposure.
AB - Several studies showed that altered expression of the miRNA-ome in maternal circulation or in placental tissue may reflect not only gestational disorders, such as preeclampsia, spontaneous abortion, preterm birth, low birth weight, or macrosomia, but also prenatal exposure to environmental pollutants. Generally, the relationships between environmental exposure, changes in miRNA expression, and gestational disorders are explored separately, producing conflicting findings. However, validation of tissue-accessible biomarkers for the monitoring of adverse pregnancy outcomes needs a systematic methodological approach that takes also into account early-life environmental exposure. To achieve this goal, exposure to xenochemicals, endogenous agents, and diet should be assessed. This study has the aim to provide a comprehensive review on the role of miRNAs as potential biomarkers for adverse pregnancy outcomes and prenatal environmental exposure.
UR - http://www.scopus.com/inward/record.url?scp=85028635869&partnerID=8YFLogxK
U2 - 10.1155/2017/8067972
DO - 10.1155/2017/8067972
M3 - Review article
AN - SCOPUS:85028635869
SN - 2314-436X
VL - 2017
JO - International Journal of Genomics
JF - International Journal of Genomics
M1 - 8067972
ER -