TY - JOUR
T1 - The Role of Selection and Migration in the Evolution of (Auto)Immunity Genes
AU - Voskarides , Konstantinos
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024
Y1 - 2024
N2 - The genetic architecture of multiple sclerosis is complicated. Additionally, the disease incidence varies per population or per geographical region. A recent study gives convincing explanations about the north–south incidence gradient of multiple sclerosis in Europe, by analyzing ancient and modern human genomes. Interestingly, the evidence shows that multiple sclerosis associated immunogenetic variants underwent positive selection in Asian and European populations. Lifestyle and pathogen infections probably shaped the overall multiple sclerosis risk. These results complete the findings of previous studies that showed that a high percentage of the autoimmunity associated genetic variants are under selection pressure.
AB - The genetic architecture of multiple sclerosis is complicated. Additionally, the disease incidence varies per population or per geographical region. A recent study gives convincing explanations about the north–south incidence gradient of multiple sclerosis in Europe, by analyzing ancient and modern human genomes. Interestingly, the evidence shows that multiple sclerosis associated immunogenetic variants underwent positive selection in Asian and European populations. Lifestyle and pathogen infections probably shaped the overall multiple sclerosis risk. These results complete the findings of previous studies that showed that a high percentage of the autoimmunity associated genetic variants are under selection pressure.
KW - Adaptation
KW - Antagonistic pleiotropy
KW - Autoimmune disease
KW - Evolutionary medicine
KW - Migration
KW - Mutation
UR - http://www.scopus.com/inward/record.url?scp=85197272184&partnerID=8YFLogxK
U2 - 10.1007/s00239-024-10182-z
DO - 10.1007/s00239-024-10182-z
M3 - Comment/debate
AN - SCOPUS:85197272184
SN - 0022-2844
JO - Journal of Molecular Evolution
JF - Journal of Molecular Evolution
ER -