TY - JOUR
T1 - The use of autologous PRP gel as an aid in the management of acute trauma wounds
AU - Kazakos, K.
AU - Lyras, D. N.
AU - Verettas, D.
AU - Tilkeridis, K.
AU - Tryfonidis, M.
PY - 2009/8
Y1 - 2009/8
N2 - Autologous platelet-rich plasma (PRP) gel is increasingly used in the treatment of a variety of soft and bony tissue defects, such as accelerating bone formation and in the management of chronic non-healing wounds. We performed this study to assess the benefits of using autologous PRP gel in the treatment of acute limb soft tissue wounds. 59 patients with acute wounds (open fractures, closed fractures with skin necrosis and friction burns) were randomised into two groups. Group A (32 patients) were treated with conventional dressings and Group B (27 patients) were managed with local application of PRP gel. Gustillo grade IIIb or IIIc open fractures were not included in this study, as these injuries required coverage with flap. The clinical endpoints were the healing rate and/or the time required to bring about adequate tissue regeneration in order to undergo reconstructive plastic surgery. The rate of wound healing rate was significantly faster in Group B at week 1, 2 and 3 (p = 0.003, p < 0.001 and p < 0.001, respectively). The mean time to plastic reconstruction in Group B was 21.26 days, S.D. = 1.35 vs 40.6 days in Group A, S.D. = 5.27 (p < 0.001). This study has shown that PRP gel treatment can be a valuable and effective aid in the management of acute trauma wounds.
AB - Autologous platelet-rich plasma (PRP) gel is increasingly used in the treatment of a variety of soft and bony tissue defects, such as accelerating bone formation and in the management of chronic non-healing wounds. We performed this study to assess the benefits of using autologous PRP gel in the treatment of acute limb soft tissue wounds. 59 patients with acute wounds (open fractures, closed fractures with skin necrosis and friction burns) were randomised into two groups. Group A (32 patients) were treated with conventional dressings and Group B (27 patients) were managed with local application of PRP gel. Gustillo grade IIIb or IIIc open fractures were not included in this study, as these injuries required coverage with flap. The clinical endpoints were the healing rate and/or the time required to bring about adequate tissue regeneration in order to undergo reconstructive plastic surgery. The rate of wound healing rate was significantly faster in Group B at week 1, 2 and 3 (p = 0.003, p < 0.001 and p < 0.001, respectively). The mean time to plastic reconstruction in Group B was 21.26 days, S.D. = 1.35 vs 40.6 days in Group A, S.D. = 5.27 (p < 0.001). This study has shown that PRP gel treatment can be a valuable and effective aid in the management of acute trauma wounds.
KW - Acute wound
KW - Platelet-rich plasma
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=67650164750&partnerID=8YFLogxK
U2 - 10.1016/j.injury.2008.05.002
DO - 10.1016/j.injury.2008.05.002
M3 - Article
C2 - 18703188
AN - SCOPUS:67650164750
SN - 0020-1383
VL - 40
SP - 801
EP - 805
JO - Injury
JF - Injury
IS - 8
ER -