Theoretical Studies Revealing Mitochondrial-Targeted Anticancer Activity of Oxovanadium (V) Complexes

Manos C. Vlasiou

doi:10.33263/LIANBS134.174

Theoretical Studies Revealing Mitochondrial-Targeted Anticancer Activity of Oxovanadium (V) Complexes

Manos C. Vlasiou

School of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

In recent years, more oxovanadium (IV/V) compounds have been tested for their cytotoxicity, with most of them having great results. Some biological evaluations of these complexes revealed several mechanisms of this activity, with most agreeing on ROS formation and mitochondria-targeted cell arrest apoptosis. Here, to evaluate the anticancer mechanism of oxovanadium (V) complexes, we used two oxovanadium (V) hydroquinone compounds with proven cytotoxicity on MDA-MB-231 breast cancer cisplatin resistance cells. This theoretical investigation showed inhibition of mitochondrial proteins and ROS generation as potential anticancer mechanisms of the oxovanadium (V) complexes.

Original language	English
Article number	174
Journal	Letters in Applied NanoBioScience
Volume	13
Issue number	4
DOIs	https://doi.org/10.33263/LIANBS134.174
Publication status	Published - 30 Dec 2024

Keywords

anticancer activity
mitochondria
Oxovanadium complexes
ROS generation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.33263/LIANBS134.174

Cite this

@article{d65b3760b8a34c21b0173c48c2fc44f6,

title = "Theoretical Studies Revealing Mitochondrial-Targeted Anticancer Activity of Oxovanadium (V) Complexes",

abstract = "In recent years, more oxovanadium (IV/V) compounds have been tested for their cytotoxicity, with most of them having great results. Some biological evaluations of these complexes revealed several mechanisms of this activity, with most agreeing on ROS formation and mitochondria-targeted cell arrest apoptosis. Here, to evaluate the anticancer mechanism of oxovanadium (V) complexes, we used two oxovanadium (V) hydroquinone compounds with proven cytotoxicity on MDA-MB-231 breast cancer cisplatin resistance cells. This theoretical investigation showed inhibition of mitochondrial proteins and ROS generation as potential anticancer mechanisms of the oxovanadium (V) complexes.",

keywords = "anticancer activity, mitochondria, Oxovanadium complexes, ROS generation",

author = "Vlasiou, {Manos C.}",

note = "Publisher Copyright: {\textcopyright} 2024 by the authors.",

year = "2024",

month = dec,

day = "30",

doi = "10.33263/LIANBS134.174",

language = "English",

volume = "13",

journal = "Letters in Applied NanoBioScience",

issn = "2284-6808",

publisher = "AMG Transcend Association",

number = "4",

}

TY - JOUR

T1 - Theoretical Studies Revealing Mitochondrial-Targeted Anticancer Activity of Oxovanadium (V) Complexes

AU - Vlasiou, Manos C.

PY - 2024/12/30

Y1 - 2024/12/30

N2 - In recent years, more oxovanadium (IV/V) compounds have been tested for their cytotoxicity, with most of them having great results. Some biological evaluations of these complexes revealed several mechanisms of this activity, with most agreeing on ROS formation and mitochondria-targeted cell arrest apoptosis. Here, to evaluate the anticancer mechanism of oxovanadium (V) complexes, we used two oxovanadium (V) hydroquinone compounds with proven cytotoxicity on MDA-MB-231 breast cancer cisplatin resistance cells. This theoretical investigation showed inhibition of mitochondrial proteins and ROS generation as potential anticancer mechanisms of the oxovanadium (V) complexes.

AB - In recent years, more oxovanadium (IV/V) compounds have been tested for their cytotoxicity, with most of them having great results. Some biological evaluations of these complexes revealed several mechanisms of this activity, with most agreeing on ROS formation and mitochondria-targeted cell arrest apoptosis. Here, to evaluate the anticancer mechanism of oxovanadium (V) complexes, we used two oxovanadium (V) hydroquinone compounds with proven cytotoxicity on MDA-MB-231 breast cancer cisplatin resistance cells. This theoretical investigation showed inhibition of mitochondrial proteins and ROS generation as potential anticancer mechanisms of the oxovanadium (V) complexes.

KW - anticancer activity

KW - mitochondria

KW - Oxovanadium complexes

KW - ROS generation

UR - http://www.scopus.com/inward/record.url?scp=85205888751&partnerID=8YFLogxK

U2 - 10.33263/LIANBS134.174

DO - 10.33263/LIANBS134.174

M3 - Article

AN - SCOPUS:85205888751

SN - 2284-6808

VL - 13

JO - Letters in Applied NanoBioScience

JF - Letters in Applied NanoBioScience

IS - 4

M1 - 174

ER -

Theoretical Studies Revealing Mitochondrial-Targeted Anticancer Activity of Oxovanadium (V) Complexes

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this