Abstract
In recent years, more oxovanadium (IV/V) compounds have been tested for their cytotoxicity, with most of them having great results. Some biological evaluations of these complexes revealed several mechanisms of this activity, with most agreeing on ROS formation and mitochondria-targeted cell arrest apoptosis. Here, to evaluate the anticancer mechanism of oxovanadium (V) complexes, we used two oxovanadium (V) hydroquinone compounds with proven cytotoxicity on MDA-MB-231 breast cancer cisplatin resistance cells. This theoretical investigation showed inhibition of mitochondrial proteins and ROS generation as potential anticancer mechanisms of the oxovanadium (V) complexes.
| Original language | English |
|---|---|
| Article number | 174 |
| Journal | Letters in Applied NanoBioScience |
| Volume | 13 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 30 Dec 2024 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- anticancer activity
- mitochondria
- Oxovanadium complexes
- ROS generation
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