Thrice weekly lymphoblastoid interferon is effective in inhibiting hepatitis B virus replication

A. S.F. Lok, I. V.D. Weller, P. Karayiannis, D. Brown, M. J.F. Fowler, J. Monjardino, H. C. Thomas, S. Sherlock

Research output: Contribution to journalArticlepeer-review

79 Citations (Scopus)

Abstract

ABSTRACT— Six patients with chronic hepatitis B virus (HBV)‐induced liver disease were treated with human lymphoblastoid interferon. Daily, alternate day or thrice weekly regimens were employed in two, one and three patients respectively. Thrice weekly intra‐muscular injections of 7.5 to 10 megaunits of interferon/m2 appeared to be as effective as daily injections in producing inhibition of HBV replication, were associated with fewer side effects and could be continued for up to 3 months. The effectiveness of this regimen in producing long‐term inhibition of viral replication must now be determined.

Original languageEnglish
Pages (from-to)45-49
Number of pages5
JournalLiver
Volume4
Issue number1
DOIs
Publication statusPublished - 1984

Keywords

  • inhibition of hepatitis B virus
  • thrice weekly lymphoblastoid interferon

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