Thrice weekly lymphoblastoid interferon is effective in inhibiting hepatitis B virus replication

A. S.F. Lok; I. V.D. Weller; P. Karayiannis; D. Brown; M. J.F. Fowler; J. Monjardino; H. C. Thomas; S. Sherlock

doi:10.1111/j.1600-0676.1984.tb00906.x

Thrice weekly lymphoblastoid interferon is effective in inhibiting hepatitis B virus replication

A. S.F. Lok, I. V.D. Weller, P. Karayiannis, D. Brown, M. J.F. Fowler, J. Monjardino, H. C. Thomas, S. Sherlock

Medical School

University College London

Research output: Contribution to journal › Article › peer-review

Abstract

ABSTRACT— Six patients with chronic hepatitis B virus (HBV)‐induced liver disease were treated with human lymphoblastoid interferon. Daily, alternate day or thrice weekly regimens were employed in two, one and three patients respectively. Thrice weekly intra‐muscular injections of 7.5 to 10 megaunits of interferon/m² appeared to be as effective as daily injections in producing inhibition of HBV replication, were associated with fewer side effects and could be continued for up to 3 months. The effectiveness of this regimen in producing long‐term inhibition of viral replication must now be determined.

Original language	English
Pages (from-to)	45-49
Number of pages	5
Journal	Liver
Volume	4
Issue number	1
DOIs	https://doi.org/10.1111/j.1600-0676.1984.tb00906.x
Publication status	Published - 1984

Keywords

inhibition of hepatitis B virus
thrice weekly lymphoblastoid interferon

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1600-0676.1984.tb00906.x

Cite this

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title = "Thrice weekly lymphoblastoid interferon is effective in inhibiting hepatitis B virus replication",

abstract = "ABSTRACT— Six patients with chronic hepatitis B virus (HBV)‐induced liver disease were treated with human lymphoblastoid interferon. Daily, alternate day or thrice weekly regimens were employed in two, one and three patients respectively. Thrice weekly intra‐muscular injections of 7.5 to 10 megaunits of interferon/m2 appeared to be as effective as daily injections in producing inhibition of HBV replication, were associated with fewer side effects and could be continued for up to 3 months. The effectiveness of this regimen in producing long‐term inhibition of viral replication must now be determined.",

keywords = "inhibition of hepatitis B virus, thrice weekly lymphoblastoid interferon",

author = "Lok, {A. S.F.} and Weller, {I. V.D.} and P. Karayiannis and D. Brown and Fowler, {M. J.F.} and J. Monjardino and Thomas, {H. C.} and S. Sherlock",

year = "1984",

doi = "10.1111/j.1600-0676.1984.tb00906.x",

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T1 - Thrice weekly lymphoblastoid interferon is effective in inhibiting hepatitis B virus replication

AU - Lok, A. S.F.

AU - Weller, I. V.D.

AU - Karayiannis, P.

AU - Brown, D.

AU - Fowler, M. J.F.

AU - Monjardino, J.

AU - Thomas, H. C.

AU - Sherlock, S.

PY - 1984

Y1 - 1984

N2 - ABSTRACT— Six patients with chronic hepatitis B virus (HBV)‐induced liver disease were treated with human lymphoblastoid interferon. Daily, alternate day or thrice weekly regimens were employed in two, one and three patients respectively. Thrice weekly intra‐muscular injections of 7.5 to 10 megaunits of interferon/m2 appeared to be as effective as daily injections in producing inhibition of HBV replication, were associated with fewer side effects and could be continued for up to 3 months. The effectiveness of this regimen in producing long‐term inhibition of viral replication must now be determined.

AB - ABSTRACT— Six patients with chronic hepatitis B virus (HBV)‐induced liver disease were treated with human lymphoblastoid interferon. Daily, alternate day or thrice weekly regimens were employed in two, one and three patients respectively. Thrice weekly intra‐muscular injections of 7.5 to 10 megaunits of interferon/m2 appeared to be as effective as daily injections in producing inhibition of HBV replication, were associated with fewer side effects and could be continued for up to 3 months. The effectiveness of this regimen in producing long‐term inhibition of viral replication must now be determined.

KW - inhibition of hepatitis B virus

KW - thrice weekly lymphoblastoid interferon

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DO - 10.1111/j.1600-0676.1984.tb00906.x

M3 - Article

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AN - SCOPUS:0021254199

SN - 0106-9543

VL - 4

SP - 45

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JO - Liver

JF - Liver

IS - 1

ER -

Thrice weekly lymphoblastoid interferon is effective in inhibiting hepatitis B virus replication

Abstract

Keywords

UN SDGs

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