Tranexamic acid and acute myocardial infarction

The plasminogen activator inhibitors have an important therapeutic role in controlling bleeding in patients with congenital and acquired coagulation disorders. They are being increasingly used in patients with blood loss and to prevent bleeding. However, these antifibrinolytic agents can also facilitate the development of thrombosis. We report a patient with severe gastrointestinal bleeding who developed acute myocardial infarction following the administration of the antifibrinolytic agent, tranexamic acid.