Transcripts of PTTG and growth factors bFGF and IGF-1 are correlated in pituitary adenomas

K. Chamaon, D. Kanakis, C. Mawrin, K. Dietzmann, E. Kirches

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The reasons for the increase of pituitary tumor-transforming gene (PTTG) transcripts in about 90% of pituitary adenomas are still not fully understood, although upregulation by basic fibroblast growth factor (bFGF) has been discussed as a potential cause. A possible influence of the Insulin like Growth Factor 1 (IGF-1) might be of interest, since this protein is also synthesized in most pituitary adenomas. Moreover, the principal regulation of the PTTG gene by IGF-1 and Insulin has been demonstrated in astrocytoma and breast cancer cells. We analyzed a large group (103 patients) of unselected clinical pituitary adenoma samples. From total RNA of frozen tumor samples (all subtypes) cDNA (complementary DNA) was synthesized and transcripts of PTTG, bFGF, IGF-1 were measured by Real-Time-PCR. Not only mRNA (messenger RNA) levels of bFGF, but also of IGF-1, correlated strongly with PTTG transcripts. This result was obtained, when all pituitary adenoma samples were included in the statistical calculations, irrespective of their subclassification. Our study suggests a connection between PTTG and IGF-1 in pituitary adenomas.

Original languageEnglish
Pages (from-to)121-126
Number of pages6
JournalExperimental and Clinical Endocrinology and Diabetes
Volume118
Issue number2
DOIs
Publication statusPublished - 2010

Keywords

  • BFGF
  • IGF-1
  • Pituitary adenoma
  • PTTG
  • Real-time PCR

Fingerprint Dive into the research topics of 'Transcripts of PTTG and growth factors bFGF and IGF-1 are correlated in pituitary adenomas'. Together they form a unique fingerprint.

  • Cite this