Abstract
To test the effect of transplantation of T-cell-depleted bone marrow on recipient immune function the results of pre-transplantation immunisation with tetanus toxoid and hepatitis-B vaccine were studied in 38 donor-recipient pairs. Immunisation ofthe donor alone resulted in transfer of an antibody response to the recipient; immunisation of both donor and recipient resulted in potentiation of the antibody response in both magnitude and duration. These findings indicate that donor T-cell-depleted marrow can transfer humoral immunity to the recipient and that appropriate pre-transplant immunisation schedules may be of benefit to the recipient.
Original language | English |
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Pages (from-to) | 339-343 |
Number of pages | 5 |
Journal | The Lancet |
Volume | 327 |
Issue number | 8477 |
DOIs | |
Publication status | Published - 15 Feb 1986 |