TRANSFER OF A FUNCTIONING HUMORAL IMMUNE SYSTEM IN TRANSPLANTATION OF T-LYMPHOCYTE-DEPLETED BONE MARROW

J. Z. Wimperis; H. G. Prentice; P. Karayiannis; M. K. Brenner; J. E. Reittie; P. D. Griffiths; A. V. Hoffbrand

doi:10.1016/S0140-6736(86)92315-9

TRANSFER OF A FUNCTIONING HUMORAL IMMUNE SYSTEM IN TRANSPLANTATION OF T-LYMPHOCYTE-DEPLETED BONE MARROW

J. Z. Wimperis
, H. G. Prentice
, P. Karayiannis
, M. K. Brenner
, J. E. Reittie
, P. D. Griffiths
, A. V. Hoffbrand

Medical School

University College London

Research output: Contribution to journal › Article › peer-review

Abstract

To test the effect of transplantation of T-cell-depleted bone marrow on recipient immune function the results of pre-transplantation immunisation with tetanus toxoid and hepatitis-B vaccine were studied in 38 donor-recipient pairs. Immunisation ofthe donor alone resulted in transfer of an antibody response to the recipient; immunisation of both donor and recipient resulted in potentiation of the antibody response in both magnitude and duration. These findings indicate that donor T-cell-depleted marrow can transfer humoral immunity to the recipient and that appropriate pre-transplant immunisation schedules may be of benefit to the recipient.

Original language	English
Pages (from-to)	339-343
Number of pages	5
Journal	The Lancet
Volume	327
Issue number	8477
DOIs	https://doi.org/10.1016/S0140-6736(86)92315-9
Publication status	Published - 15 Feb 1986

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title = "TRANSFER OF A FUNCTIONING HUMORAL IMMUNE SYSTEM IN TRANSPLANTATION OF T-LYMPHOCYTE-DEPLETED BONE MARROW",

abstract = "To test the effect of transplantation of T-cell-depleted bone marrow on recipient immune function the results of pre-transplantation immunisation with tetanus toxoid and hepatitis-B vaccine were studied in 38 donor-recipient pairs. Immunisation ofthe donor alone resulted in transfer of an antibody response to the recipient; immunisation of both donor and recipient resulted in potentiation of the antibody response in both magnitude and duration. These findings indicate that donor T-cell-depleted marrow can transfer humoral immunity to the recipient and that appropriate pre-transplant immunisation schedules may be of benefit to the recipient.",

author = "Wimperis, \{J. Z.\} and Prentice, \{H. G.\} and P. Karayiannis and Brenner, \{M. K.\} and Reittie, \{J. E.\} and Griffiths, \{P. D.\} and Hoffbrand, \{A. V.\}",

year = "1986",

month = feb,

day = "15",

doi = "10.1016/S0140-6736(86)92315-9",

language = "English",

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T1 - TRANSFER OF A FUNCTIONING HUMORAL IMMUNE SYSTEM IN TRANSPLANTATION OF T-LYMPHOCYTE-DEPLETED BONE MARROW

AU - Wimperis, J. Z.

AU - Prentice, H. G.

AU - Karayiannis, P.

AU - Brenner, M. K.

AU - Reittie, J. E.

AU - Griffiths, P. D.

AU - Hoffbrand, A. V.

PY - 1986/2/15

Y1 - 1986/2/15

N2 - To test the effect of transplantation of T-cell-depleted bone marrow on recipient immune function the results of pre-transplantation immunisation with tetanus toxoid and hepatitis-B vaccine were studied in 38 donor-recipient pairs. Immunisation ofthe donor alone resulted in transfer of an antibody response to the recipient; immunisation of both donor and recipient resulted in potentiation of the antibody response in both magnitude and duration. These findings indicate that donor T-cell-depleted marrow can transfer humoral immunity to the recipient and that appropriate pre-transplant immunisation schedules may be of benefit to the recipient.

AB - To test the effect of transplantation of T-cell-depleted bone marrow on recipient immune function the results of pre-transplantation immunisation with tetanus toxoid and hepatitis-B vaccine were studied in 38 donor-recipient pairs. Immunisation ofthe donor alone resulted in transfer of an antibody response to the recipient; immunisation of both donor and recipient resulted in potentiation of the antibody response in both magnitude and duration. These findings indicate that donor T-cell-depleted marrow can transfer humoral immunity to the recipient and that appropriate pre-transplant immunisation schedules may be of benefit to the recipient.

UR - https://www.scopus.com/pages/publications/0022656382

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DO - 10.1016/S0140-6736(86)92315-9

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AN - SCOPUS:0022656382

SN - 0140-6736

VL - 327

SP - 339

EP - 343

JO - The Lancet

JF - The Lancet

IS - 8477

ER -

TRANSFER OF A FUNCTIONING HUMORAL IMMUNE SYSTEM IN TRANSPLANTATION OF T-LYMPHOCYTE-DEPLETED BONE MARROW

Abstract

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