TY - JOUR
T1 - Type 2 diabetes susceptibility in the Greek-Cypriot population
T2 - Replication of associations with TCF7L2, FTO, HHEX, SLC30A8 and IGF2BP2 polymorphisms
AU - Votsi, Christina
AU - Toufexis, Costas
AU - Michailidou, Kyriaki
AU - Antoniades, Athos
AU - Skordis, Nicos
AU - Karaolis, Minas
AU - Pattichis, Constantinos S.
AU - Christodoulou, Kyproula
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Type 2 diabetes (T2D) has been the subject of numerous genetic studies in recent years which revealed associations of the disease with a large number of susceptibility loci. We hereby initiate the evaluation of T2D susceptibility loci in the Greek-Cypriot population by performing a replication case-control study. One thousand and eighteen individuals (528 T2D patients, 490 controls) were genotyped at 21 T2D susceptibility loci, using the allelic discrimination method. Statistically significant associations of T2D with five of the tested single nucleotide polymorphisms (SNPs) (TCF7L2 rs7901695, FTO rs8050136, HHEX rs5015480, SLC30A8 rs13266634 and IGF2BP2 rs4402960) were observed in this study population. Furthermore, 14 of the tested SNPs had odds ratios (ORs) in the same direction as the previously published studies, suggesting that these variants can potentially be used in the Greek-Cypriot population for predictive testing of T2D. In conclusion, our findings expand the genetic assessment of T2D susceptibility loci and reconfirm five of the worldwide established loci in a distinct, relatively small, newly investigated population.
AB - Type 2 diabetes (T2D) has been the subject of numerous genetic studies in recent years which revealed associations of the disease with a large number of susceptibility loci. We hereby initiate the evaluation of T2D susceptibility loci in the Greek-Cypriot population by performing a replication case-control study. One thousand and eighteen individuals (528 T2D patients, 490 controls) were genotyped at 21 T2D susceptibility loci, using the allelic discrimination method. Statistically significant associations of T2D with five of the tested single nucleotide polymorphisms (SNPs) (TCF7L2 rs7901695, FTO rs8050136, HHEX rs5015480, SLC30A8 rs13266634 and IGF2BP2 rs4402960) were observed in this study population. Furthermore, 14 of the tested SNPs had odds ratios (ORs) in the same direction as the previously published studies, suggesting that these variants can potentially be used in the Greek-Cypriot population for predictive testing of T2D. In conclusion, our findings expand the genetic assessment of T2D susceptibility loci and reconfirm five of the worldwide established loci in a distinct, relatively small, newly investigated population.
KW - Association studies
KW - Greek-cypriot population
KW - Population studies
KW - Susceptibility loci
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85009758624&partnerID=8YFLogxK
U2 - 10.3390/genes8010016
DO - 10.3390/genes8010016
M3 - Article
AN - SCOPUS:85009758624
SN - 2073-4425
VL - 8
JO - Genes
JF - Genes
IS - 1
M1 - 35
ER -