Update on fertility in thalassaemia major

Nicos Skordis, Loizos Petrikkos, Meropi Toumba, Krikor Simamonian, Michael Hadjigavriel, Maria Sitarou, Annita Kolnakou, George Skordos, Evi Pangalou, Soteroulla Christou

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Therapeutic advances in thalassaemia major have significantly increased the average lifespan and improved the quality of life in thalassaemic patients. Therefore attainment of reproductive capacity and creation of a family has become a great task. Endocrine complications due to haemosiderosis and especially hypoaonadotrophic hypogonadism are still present in a significant number of patients worldwide and often becomes a barrier in their desire for parenthood. The report of 358 successful pregnancies so far has provided strong evidence not only for the absence of any deleterious effect on the course of thalassaemia but also for the safety of the pregnancy in the thalassaemic woman. Ovarian function is well preserved in women suffering primary or secondary amenorrhea as they become able to conceive following a closely monitored stimulation therapy. The desire of the thalassaemic woman to become a mother is always viewed with special caution and sensitivity. Ambitions of this sort pose numerous medico legal and ethical issues that need to be addressed prudently if the patients' quality of life is to be optimized.

Original languageEnglish
Pages (from-to)296-302
Number of pages7
JournalPediatric Endocrinology Reviews
Volume2
Issue numberSUPPL. 2
Publication statusPublished - Dec 2004

Keywords

  • Fertility
  • Pregnancy
  • Thalassemia

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    Skordis, N., Petrikkos, L., Toumba, M., Simamonian, K., Hadjigavriel, M., Sitarou, M., Kolnakou, A., Skordos, G., Pangalou, E., & Christou, S. (2004). Update on fertility in thalassaemia major. Pediatric Endocrinology Reviews, 2(SUPPL. 2), 296-302.