TY - JOUR
T1 - Vibroacoustic stimulation is not associated with sudden fetal catecholamine release
AU - Fisk, Nicholas M.
AU - Nicolaidis, Peter K.
AU - Arulkumaran, Sabaratnam
AU - Weg, M. Walter
AU - Tannirandorn, Yuen
AU - Nicolini, Umberto
AU - Parkes, Michael J.
AU - Rodeck, Charles H.
PY - 1991
Y1 - 1991
N2 - The safety of vibroacoustic stimulation (VAS), which produces marked changes in fetal heart rate, movements and behavioural state, remains unclear. In order to determine whether VAS is associated with catecholamine release, we measured plasma noradrenaline and adrenaline in 13 appropriately grown normoxaemic fetuses between 28 and 40 weeks gestation immediately before and 60 and 75 s after VAS. Over this time interval, VAS is known to increase fetal heart rate. There was no significant change in either noradrenaline (median change = +0.06 ng/ml, P = 0.26) or adrenaline levels (median changes = +0.03 ng/ml, P = 0.4). This study suggests that sympathoadrenal activation is not part of the fetal response to VAS. These findings do not support the recent suggestion that VAS may be deleterious to the fetus by provoking sudden release of catecholamines.
AB - The safety of vibroacoustic stimulation (VAS), which produces marked changes in fetal heart rate, movements and behavioural state, remains unclear. In order to determine whether VAS is associated with catecholamine release, we measured plasma noradrenaline and adrenaline in 13 appropriately grown normoxaemic fetuses between 28 and 40 weeks gestation immediately before and 60 and 75 s after VAS. Over this time interval, VAS is known to increase fetal heart rate. There was no significant change in either noradrenaline (median change = +0.06 ng/ml, P = 0.26) or adrenaline levels (median changes = +0.03 ng/ml, P = 0.4). This study suggests that sympathoadrenal activation is not part of the fetal response to VAS. These findings do not support the recent suggestion that VAS may be deleterious to the fetus by provoking sudden release of catecholamines.
KW - cardiotocography
KW - catecholamines
KW - fetal monitoring
KW - vibroacoustic stimulation
UR - http://www.scopus.com/inward/record.url?scp=0026012179&partnerID=8YFLogxK
U2 - 10.1016/0378-3782(91)90202-E
DO - 10.1016/0378-3782(91)90202-E
M3 - Article
C2 - 2055172
AN - SCOPUS:0026012179
SN - 0378-3782
VL - 25
SP - 11
EP - 17
JO - Early Human Development
JF - Early Human Development
IS - 1
ER -