Which patients with chronic hepatitis B virus infection will respond to α‐interferon therapy? A statistical analysis of predictive factors

M. Gary Brook, Peter Karayiannis, Howard C. Thomas

Research output: Contribution to journalArticle

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Abstract

Twenty‐one pretreatment variables were assessed for their significance in response prediction using data from 114 patients given α‐interferon for chronic hepatitis B virus infection. In those patients who had received a minimum of 90 million units per m2 total dose over 12 weeks, a negative anti‐human immunodeficiency virus antibody status (p < 0.001), chronic active hepatitis on liver biopsy (p < 0.005), high AST level (p < 0.001), low hepatitis B virus DNA level (p < 0.001) and a history of acute hepatitis (p < 0.005) were all associated with an increased likelihood of response on univariate analysis. On stepwise logistic regression analysis, hepatitis B virus DNA, AST and a history of acute hepatitis predicted response independently (p < 0.05). The most reliable combination of predictive factors was a negative anti‐human immunodeficiency virus antibody status, with either a positive history of acute icteric hepatitis and AST > 45 IU per liter or no history of acute icteric hepatitis and AST > 85 IU per liter, which predicted response in 77% with a specificity of 79% (p < 0.001). The loss of HBsAg in addition to HBeAg and hepatitis B virus DNA was more likely to occur in patients with chronic infection of <2 years duration (p < 0.001).

Original languageEnglish
Pages (from-to)761-763
Number of pages3
JournalHepatology
Volume10
Issue number5
DOIs
Publication statusPublished - 1989

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Chronic Hepatitis B
Virus Diseases
Hepatitis B virus
Interferons
Statistical Factor Analysis
Hepatitis B e Antigens
Hepatitis B Surface Antigens
Hepatitis
Therapeutics
Viruses
Antibodies
DNA
Infection

Cite this

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abstract = "Twenty‐one pretreatment variables were assessed for their significance in response prediction using data from 114 patients given α‐interferon for chronic hepatitis B virus infection. In those patients who had received a minimum of 90 million units per m2 total dose over 12 weeks, a negative anti‐human immunodeficiency virus antibody status (p < 0.001), chronic active hepatitis on liver biopsy (p < 0.005), high AST level (p < 0.001), low hepatitis B virus DNA level (p < 0.001) and a history of acute hepatitis (p < 0.005) were all associated with an increased likelihood of response on univariate analysis. On stepwise logistic regression analysis, hepatitis B virus DNA, AST and a history of acute hepatitis predicted response independently (p < 0.05). The most reliable combination of predictive factors was a negative anti‐human immunodeficiency virus antibody status, with either a positive history of acute icteric hepatitis and AST > 45 IU per liter or no history of acute icteric hepatitis and AST > 85 IU per liter, which predicted response in 77{\%} with a specificity of 79{\%} (p < 0.001). The loss of HBsAg in addition to HBeAg and hepatitis B virus DNA was more likely to occur in patients with chronic infection of <2 years duration (p < 0.001).",
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Which patients with chronic hepatitis B virus infection will respond to α‐interferon therapy? A statistical analysis of predictive factors. / Brook, M. Gary; Karayiannis, Peter; Thomas, Howard C.

In: Hepatology, Vol. 10, No. 5, 1989, p. 761-763.

Research output: Contribution to journalArticle

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